Austin Soplata, Boston University
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Better understanding of propofol mechanisms could lead to more targeted anesthetics
Clarify mechanistic differences between between anesthesia and sleep, including rhythms
Decreases thalamocortical (TC) cell H-current conductance ( )
Decreases Excitation from brainstem ()
Increase of and decrease of TC cell H-current are required for thalamic Alpha oscillations
Thalamic Alpha oscillations are sustained spindles
Interaction between thalamic Alpha and Slow Wave Activity can produce propofol phase-amplitude coupling regimes
Sustained Alpha does not occur normally
increase is a necessary factor for sustained Alpha
TC cell H-current decrease is also a necessary factor for sustained Alpha
Increase of and decrease of TC cell H-current are required for thalamic Alpha oscillations
Thalamic Alpha oscillations are sustained spindles
Interaction between thalamic Alpha and Slow Wave Activity can produce propofol phase-amplitude coupling regimes
Propofol thalamic alpha takes advantage of thalamic spindle dynamics (e.g. )
Enhanced inhibition enables more spiking/oscillating due to T-current and H-current interplay
Increase of and decrease of TC cell H-current are required for thalamic Alpha oscillations
Thalamic Alpha oscillations are sustained spindles
Interaction between thalamic Alpha and Slow Wave Activity can produce propofol phase-amplitude coupling regimes